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Scientific Basis for Managing PFAS as a Chemical Class
This commentary presents a scientific basis for managing as one chemical class the thousands of chemicals known as PFAS (per- and polyfluoroalkyl substances). The class includes...Measurement of Novel, Drinking Water-Associated PFAS in Blood from Adults and...
BACKGROUND: From 1980 to 2017, a fluorochemical manufacturing facility discharged wastewater containing poorly understood per- and polyfluoroalkyl substances (PFAS) to the Cape...Factors associated with per- and polyfluoroalkyl substances (PFAS) serum...
In 2017, people living in New Hanover County, North Carolina, learned that for ∼40 years they were unknowingly exposed to per- and polyfluoroalkyl substances (PFAS) through...Estimation of the Half-Lives of Recently Detected Per- and Polyfluorinated...
To estimate half-lives for novel fluoroethers, the GenX Exposure Study obtained two serum measurements for perand polyfluoroalkyl substances (PFAS) for 44 participants of age...Bioaccumulation of Novel Per- and Polyfluoroalkyl Substances in Mice Dosed...
Per- and polyfluoroalkyl substances (PFASs) are widespread in the blood of the general human population, and their bioaccumulation is of considerable scientific and regulatory...Zürich Statement on Future Actions on Per- and Polyfluoroalkyl Substances...
Per- and polyfluoroalkyl substances (PFASs) are man-made chemicals that contain at least one perfluoroalkyl moiety, –CnF2n–. To date, over 4,000 unique PFASs have been used in...Widening the Lens on PFASs: Direct Human Exposure to Perfluoroalkyl Acid...
Determining health risks associated with per-/polyfluoroalkyl substances (PFASs) is a highly complex problem requiring massive efforts for scientists, risk assessors, and...Using Chicken Embryo as a Powerful Tool in Assessment of Developmental...
Chicken embryos are a classical model in developmental studies. During the development of chicken embryos, the time window of heart development is welldefined, and it is...The high persistence of PFAS is sufficient for their management as a chemical...
Per- and polyfluoroalkyl substances (PFAS) are a class of synthetic organic substances with diverse structures, properties, uses, bioaccumulation potentials and toxicities....The concept of essential use for determining when uses of PFASs can be phased...
Because of the extreme persistence of per- and polyfluoroalkyl substances (PFASs) and their associated risks, the Madrid Statement argues for stopping their use where they are...Strategies for grouping per- and polyfluoroalkyl substances (PFAS) to protect...
Grouping strategies are needed for per- and polyfluoroalkyl substances (PFAS), in part, because it would be time and resource intensive to test and evaluate the more than 4700...Scientists’ Statement on the Chemical Definition of PFASs
The undersigned are scientists with expertise in per- and polyfluoroalkyl substances (PFASs) and/or the management of chemicals. We assert that the Organization for Economic Co-...PFAS Toxicity: What’s True, What’s Not, and What Really Matters
A substantial body of evidence exists demonstrating that exposure to per- and polyfluoroalkyl substances (PFASs) poses a risk to human health. Data from epidemiological studies...Per- and Polyfluoroalkyl Substance Toxicity and Human Health Review: Current...
Reports of environmental and human health impacts of per- and polyfluoroalkyl substances (PFAS) have greatly increased in the peer-reviewed literature. The goals of the present...Per- and Polyfluoroalkyl Substances (PFAS) Enhance Cholesterol Accumulation...
Epidemiological studies and in vivo animal models have shown that exposure to PFAS can lead to cardiovascular toxicity and promote atherosclerosis. In this study, we explored...Per- and polyfluoroalkyl substances alter innate immune function: evidence...
Per- and polyfluoroalkyl substances (PFASs) are a large class of compounds used in a variety of processes and consumer products. Their unique chemical properties make them...Letter to the editors regarding “The conundrum of the PFOA human half-life,...
Campbell et al. (2022) propose that many studies estimating the human half-life of perfluorooctanoic acid (PFOA) are significantly confounded by lack of accounting for ongoing...Legacy and emerging per- and polyfluoroalkyl substances suppress the...
Per- and polyfluoroalkyl substances (PFASs) are used in a multitude of processes and products, including nonstick coatings, food wrappers, and fire-fighting foams. These...Information Requirements under the Essential-Use Concept: PFAS Case Studies
Per- and polyfluoroalkyl substances (PFAS) are a class of substances for which there are widespread concerns about their extreme persistence in combination with toxic effects....